Faculty

Ph.D. (Prof. K. K. Balasubramanian) IIT Madras,

Postdoctoral fellow:

1. Prof. Alfred Hassner at Bar-Ilan University, Israel.

2. Prof. Binne Zwanenburg at the University of Nijmegen, The Netherlands.

3. JSPS postdoctoral fellow with Prof. Yasuyuki Kita at Osaka University, Japan. Indian Institute of Technology Delhi, 2000-present.

Research Interests

Our group’s research activities mainly focus on the synthesis of biologically active natural products and their analogues from readily available and cheap carbohydrates as a “chiral pool” through some novel and interesting chemical transformations. Our main aim is to develop a “Diversity Oriented Approach” towards the synthesis of a library of skeletally distinct small and novel molecules with potential biological applications. Glycals (carbohydrate derived enol-ethers), which are perhaps the most versatile monosaccharides, are being extensively exploited by us, as convenient starting materials, to realize our research focus.
Illustrative examples of natural products and their mimics that were synthesized recently and are being pursued currently in our lab include, 1-deoxy-L-gulonojirimycin, DMDP analogues, amino-DMDP analogues, chiral 2,6-diazabicylo[3.2.1]octan-4,8-diol (a chiral conformationally restricted diamine), (‒)-pochonicine stereoisomers, steviamine stereoisomers, conduramines, (+)-anisomycin, bulgecinine, kirkamide etc. Apart from synthesis, we also carry out the inhibition studies of new compounds that were/are being synthesized in our lab. Some of these compounds display inhibition against glycosidases, SOD1 fibril formation etc.

Selected Publications

1. U. K. Mishra, Y. S. Sanghvi, E. Martin and N. G. Ramesh, Supramolecular Architecture through Self-organization of Janus-faced Homoazanucleosides, J. Org. Chem. 2021, 86, 367-378.
2. R. V. Salunke, P. K. Mishra, Y. S. Sanghvi and N. G. Ramesh, Synthesis of Novel Homoazanucleosides and their Peptidyl Analogs, Org. Biomol. Chem. 2020, 18, 5639-5651.
3. U. K. Mishra and N. G. Ramesh, A carbohydrate based straightforward approach to trans-4-hydroxy-D-proline and trans-4-hydroxy-D-prolinol, Tetrahedron Lett. 2020, 61, 152081.
4. V. K. Harit and N. G. Ramesh, A Common Strategy Towards the Synthesis of 1,4-Dideoxy-1,4-imino-L-xylitol, diacetyl (+)-anisomycin and amino-substituted piperidine iminosugars, Carbohydr. Res., 2020, 492, 107988.
5. R. V. Salunke and N. G. Ramesh, Divergent Synthesis of Amino-sustituted Indolizidine Alkaloids, Decahydropyrazino[2,1,6-cd]pyrrolizine Triols and (-)-Pochonicine Stereoisomers, Eur. J. Org. Chem. 2020, 2626-2640.
6. U. K. Mishra and N. G. Ramesh, A Glyal Based Approach to the Synthesis of (+)-Bulgecinine, 3-Hydrozy-2,5-dihydroxymethylpyrolidine and 2-Oxapyrrolizidin-3-one, Carbohydr. Res. 2020, 489, 107931.
7. V. K. Harit and N. G. Ramesh, Ring closing metathesis (RCM) approach to the synthesis of conduramine B-2, ent-conduramine F-2, aminocyclopentitol and trihydroxyazepane, Org. Biomol. Chem. 2019, 17, 5951-5961.
8. V. Santhanam, P. Pant, B. Jayaram and N. G. Ramesh, Design, Synthesis and Glycosidase Inhibition Studies of Novel Triazole Fused Iminocyclitol-δ-lactams, Org. Biomol. Chem. 2019, 17, 1130-1140.